CC-4066 in Acute Pancreatitis
Acute Pancreatitis (AP) is a sudden severe inflammation of the pancreas gland that begins in the pancreatic acinar cells that produce digestive enzymes. Pancreatic necrosis, systemic inﬂammatory response syndrome, multiple organ failure and sepsis are characteristic of the disease which results in significant mortality and is currently without disease-modifying therapy. The disease is extremely painful requiring hospitalisation of between 5 – 30 days duration. In most cases the disease is caused either by gallstones blocking drainage of the bile duct and exposing the acinar cells to the toxic effects of bile acid or by excessive alcohol consumption. Both factors cause necrosis of acinar cells by either direct toxicity (bile acids) or by amplifying physiological Ca2+ signals leading to necrotic cell death (alcohol).
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